Thymosin Beta-4

Thymosin Beta-4 (Tβ4) is one of the most abundant peptides in your body, found in virtually every cell except red blood cells. It's your body's natural "repair signal" that orchestrates healing after injury. **What does it do?** Thymosin Beta-4 controls actin, a protein that forms the "skeleton" inside your cells and enables them to move. When tissue is damaged, Tβ4 helps cells migrate to the injury site, promotes blood vessel formation, and reduces inflammation and scarring. **What the research shows:** • Accelerates wound healing in skin, cornea, and heart tissue • Reduces inflammation and scar tissue formation • Promotes new blood vessel growth (angiogenesis) • Supports hair follicle development • May protect the nervous system and support nerve regeneration **Where it's been studied:** Clinical applications include corneal injury repair, skin wounds, burns, and cardiac protection after heart attacks. **TB-500 connection:** TB-500 is a synthetic version of Thymosin Beta-4 commonly used in research and veterinary medicine. **Important to know:** While research is promising, Thymosin Beta-4 is not FDA-approved for any condition. Most evidence comes from animal studies and early human trials. --- **Sources:** Goldstein AL, et al. (2022) Current Protein & Peptide Science. DOI:10.2174/1389203724666221201093500 | Xing Y, et al. (2021) Chinese Journal of Burns. DOI:10.3760/cma.j.cn501120-20210221-00059

Approved for no systemic indication; strongest human data are ophthalmic (corneal healing); evidence for muscle/tendon/performance use is largely anecdotal or preclinical; WADA-banned in sport; long-term systemic safety data are limited.

43-amino-acid actin-sequestering peptide present in most tissues; promotes cell migration, angiogenesis, and anti-inflammatory/anti-scarring responses. Systemic half-life is short (minutes), which is why sustained-release or ophthalmic formulations (RGN-259) and frequent dosing are used in trials.