GLP-1 Weight Loss Calculator
11 medications · 62+ research citations — dosing references from FDA prescribing information and published trials; timeline estimates are model-based projections, not clinical claims.
Compiled from published research · Last updated: January 2026
This GLP-1 weight-loss calculator projects a timeline using the weight-loss ranges reported in published trials for GLP-1 medications — approved drugs such as Wegovy (semaglutide), Mounjaro (tirzepatide), and Saxenda (liraglutide), plus investigational compounds — each cited from peer-reviewed research. Enter your current weight, goal weight, height, and activity level to estimate weekly loss, total timeline, and BMI change. Timeline projections are model estimates, not clinical claims; approved-drug dosing references follow FDA titration schedules.
Calculate Your Results
Your Results
GLP-1 Medications (11)
Click to selectFDA-Approved
| Medication | Weight Loss | Citations |
|---|---|---|
Wegovy / Ozempic semaglutide | 15-17% | 12 |
Mounjaro / Zepbound tirzepatide | 20-25% | 4 |
Saxenda / Victoza liraglutide | 5-10% | 3 |
Investigational
| Medication | Phase | Weight Loss | Citations |
|---|---|---|---|
| Retatrutide | Phase 2 | 24-27% | 6 |
| Survodutide | Phase 2 | 18-20% | 6 |
| Mazdutide | Phase 3 | 15-18% | 6 |
| CagriSema | Phase 2 | 20-24% | 6 |
| Orforglipron | Phase 2 | 12-15% | 6 |
| Pemvidutide | Phase 2 | 15-18% | 5 |
| Ecnoglutide | Phase 2 | 12-15% | 4 |
| Bioglutide | Phase 1b/2a | 10-12% | 4 |
Wegovy Titration Schedule
View Source →| Phase | Weeks | Dose |
|---|---|---|
| initiation | 1-4 | 0.25 mg |
| escalation | 5-8 | 0.5 mg |
| escalation | 9-12 | 1 mg |
| escalation | 13-16 | 1.7 mg |
| maintenance | 17+ | 2.4 mg |
Citations: Wegovy (12)
- Wegovy (semaglutide) FDA Prescribing InformationFDA Drug Label · 2021
- Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)New England Journal of Medicine · 2021
Frequently Asked Questions
How much weight can I lose on Wegovy (semaglutide)?
Clinical trials show Wegovy users lose an average of 15-17% of their body weight over 68 weeks. For a 200 lb person, this equates to approximately 30-34 lbs. Results vary based on diet, exercise, and individual metabolism.
What is the Wegovy titration schedule?
Wegovy follows a 16-week titration: 0.25mg for weeks 1-4, 0.5mg for weeks 5-8, 1mg for weeks 9-12, 1.7mg for weeks 13-16, then 2.4mg maintenance dose. This gradual increase minimizes GI side effects.
Is Mounjaro (tirzepatide) more effective than Wegovy?
Yes, clinical data suggests Mounjaro produces greater weight loss (20-25%) compared to Wegovy (15-17%). Mounjaro is a dual GIP/GLP-1 agonist, which may explain its enhanced efficacy for weight loss.
How long does it take to see results with GLP-1 medications?
Most patients notice reduced appetite within 1-2 weeks. Measurable weight loss typically begins by week 4-8. Maximum weight loss is usually achieved between 12-18 months of treatment.
Are GLP-1 medications safe for long-term use?
FDA-approved GLP-1 medications have been studied for long-term safety. Common side effects include nausea, constipation, and injection site reactions. Rare but serious risks include pancreatitis and thyroid tumors. Always consult your healthcare provider.
Do I need a prescription for GLP-1 weight loss medications?
Yes, all GLP-1 receptor agonists for weight loss (Wegovy, Saxenda, Zepbound) require a prescription. They are typically prescribed for adults with BMI ≥30 or BMI ≥27 with weight-related conditions.
GLP-1 medications require a prescription. This calculator provides estimates only and is not medical advice. Consult a healthcare professional before starting any medication.
Methodology
Timeline model. The projected timeline is a model estimate: each medication's reported trial-average weight loss (from data/glp1-titration.json, e.g. "15-17%") is spread over a 52-week trial-equivalent window, then applied to your current weight. It is not a clinical claim and actual results vary. Approved-drug dosing references follow FDA titration schedules; investigational compounds are labelled as such.
Sources. Medication dosing, weight-loss ranges, and titration schedules are drawn from the cited dataset (62+ research citations) bundled in data/glp1-titration.json, with per-medication source URLs shown on this page.
Last reviewed: — research-planning reference; not medical advice.