TB-500

TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), one of the most abundant peptides in your body. It's found in nearly every cell and plays a crucial role in how your body heals itself. **What does it do?** TB-500 works by regulating actin, a protein essential for cell movement and structure. When tissue is damaged, TB-500 helps cells migrate to the injury site and promotes the formation of new blood vessels — essentially fast-tracking your body's natural repair process. **What the research shows:** • Promotes healing across multiple tissue types: skin, muscle, tendons, ligaments, heart, and eyes • Reduces inflammation and scar tissue formation • Supports new blood vessel growth (angiogenesis) • May protect heart tissue and improve cardiac function after injury • Widely used in veterinary medicine for racehorses **Common uses:** Athletes and researchers explore TB-500 for injury recovery, particularly for stubborn tendon and ligament issues that heal slowly on their own. **Important to know:** TB-500 is banned by WADA in competitive sports. While animal and veterinary research is extensive, controlled human clinical trials remain limited. --- **Sources:** Goldstein AL, et al. (2022) Current Protein & Peptide Science. DOI:10.2174/1389203724666221201093500 | Xing Y, et al. (2021) Chinese Journal of Burns. DOI:10.3760/cma.j.cn501120-20210221-00059

TB-500 sold as a research peptide is typically a thymosin beta-4 fragment without published pharmacokinetic, dosing, or safety data; clinical evidence comes from the full-length protein. A 2026 scoping review highlights heterogeneous study quality and the need for standardized trials. No regulatory approval exists for human use.

Administered by subcutaneous or intramuscular injection in research protocols. Full-length thymosin beta-4 has a short plasma half-life; the TB-500 fragment's pharmacokinetics are not characterized in published trials. Mechanism: actin-binding (LKKTETQ motif) promotes cell migration and tissue repair.