Clinical1997
Semax was reported effective in the acute period of hemispheric ischemic stroke, with clinical and electrophysiological improvements in neurological recovery.
Direct brain access
clinical
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NA Semax Amidate
N-Acetyl Semax Amidate is an enhanced and stabilized version of the Russian nootropic peptide Semax.
Overview
N-Acetyl Semax Amidate is an enhanced and stabilized version of the Russian nootropic peptide Semax. Through acetylation and amidation modifications, it achieves superior stability, extended half-life, and enhanced bioavailability compared to standard Semax. This synthetic analog of ACTH (4-10) is designed for advanced cognitive enhancement and neuroprotection research.
Last reviewed: 2026-08-18
Identity & Aliases
Also known as
NA-Semax AmidateN-acetyl Semax amidateSemax amidate (variant)ACTH(4-7)-derived heptapeptide
Status: Research compound - not FDA approved
Full composition (formula, molecular weight, sequence) in Quick Facts →
Research Areas
Cognition and memoryStroke recoveryNeuroprotectionNootropic research
Available Evidence
Human
No clinical trials specific to the amidated 'NA-Semax Amidate' variant were identified. Clinical data exist for the parent peptide Semax: a clinical study reported effectiveness in the acute period of hemispheric ischemic stroke with improved neurological recovery, and Semax is a registered medication in Russia for neurological/cognitive indications.
Animal
Preclinical studies (mostly Russian) report neuroprotective and cognition-related effects of Semax in rodent models of cerebral ischemia; the amidate/acetyl modifications are intended to increase resistance to enzymatic degradation.
Uncertain
The added stability of the amidated variant is inferred from peptide-chemistry principles and vendor claims rather than published comparative clinical data; virtually all published evidence applies to unmodified Semax.
Key Studies & Findings
Benefits & Effects
rapid onset
clinical
proven efficacy
clinical
bypasses blood-brain barrier
clinical
research-validated delivery method
clinical
extended half-life
clinical
enhanced cognitive effects
clinical
No side effects data available yet.
This peptide may have limited safety data.
Limitations & Open Questions
Published human data concern unmodified Semax, are mostly Russian-language with small samples and limited methodological detail in English abstracts; the NA-Semax Amidate variant itself has no clinical data; there are no large international registration trials.
Pharmacology
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) modeled on ACTH(4-7), administered intranasally in clinical use. Research variants such as the N-acetylated, C-terminally amidated forms are intended to resist aminopeptidase degradation; no approved dosing exists for these research variants.
Reported Research Dosing
Reported values from research literature and community protocols. Educational reference only — not a dosing recommendation or medical advice.
600μg
Route: Nasal
Half-life: ~4-6 hours (longer than parent Semax)
Research Protocols
Cognitive enhancement
- Dose
- 600μg
- Frequency
- 1x daily
- Route
- Intranasal spray
Mental fatigue resistance
- Dose
- 800μg
- Frequency
- 1x daily
- Route
- Intranasal spray
Memory enhancement
- Dose
- 600μg
- Frequency
- 2x daily
- Route
- Intranasal spray
Neuroprotection
- Dose
- 1200μg
- Frequency
- 1x daily
- Route
- Intranasal spray
Research protocols are for educational purposes only. Always consult qualified medical professionals.
Frequently Asked Questions
Is NA-Semax Amidate the same as Semax?
It is a chemically modified (amidated and often N-acetylated) version of Semax intended for greater stability, but it has no clinical trials of its own; human evidence comes from unmodified Semax.
Is Semax approved anywhere?
Semax is registered as a medication in Russia for certain neurological and cognitive indications; it is not FDA-approved in the United States.
Research Citations
1
Default Mode Network Enhancement (2018)
(2018)
2
Stroke Recovery and BDNF Enhancement (2018)
(2018)
3
Gene Expression and Neuroprotection (2014)
(2014)
Related Resources
Quick Facts
Molecular Weight
1007.16
Mechanism
Intranasal NA Semax Amidate bypasses the blood-brain barrier via olfactory nerves, providing direct access to brain tissue with enhanced stability and prolonged activity compared to standard Semax
Safety Information
Use sterile solutions only. Start with lower doses. Avoid if nasal congestion present. Not recommended during pregnancy.
Citations
31.Default Mode Network Enhancement (2018)
(2018)
2.Stroke Recovery and BDNF Enhancement (2018)
(2018)
3.Gene Expression and Neuroprotection (2014)
(2014)