BPC-157

BPC-157, short for Body Protection Compound-157, is a 15-amino acid peptide naturally found in human gastric (stomach) juice. Think of it as your body's built-in repair mechanism, amplified. **What does it do?** Research shows BPC-157 acts like a cellular "handyman" — it helps your body repair damaged tissues faster, whether that's tendons, ligaments, muscles, or your gut lining. It works by boosting blood vessel formation (angiogenesis) and stimulating the production of collagen, the protein that holds your tissues together. **Key research findings:** • Accelerates healing of soft tissue injuries in animal studies • Protects and heals the gastrointestinal tract • May help counteract damage from NSAIDs (like ibuprofen) • Phase II clinical trials for ulcerative colitis showed no significant side effects • No lethal dose has been established in toxicology studies **Important to know:** While animal research is extensive and promising, human clinical studies remain limited. Most evidence comes from rodent and cell studies. --- **Sources:** Seiwerth S, et al. (2018) Current Pharmaceutical Design. DOI:10.2174/1381612824666180712110447 | Gwyer D, et al. (2019) Cell Tissue Research. DOI:10.1007/s00441-019-03016-8 | Kang EA, et al. (2024) Inflammopharmacology. DOI:10.1007/s10787-024-01499-8

Evidence is dominated by a single research group's animal models with limited independent replication; no adequately powered randomized human trials exist; mechanism (angiogenesis, nitric oxide modulation) remains incompletely characterized; formulation, dosing and long-term human safety are unestablished.

Pentadecapeptide (15 amino acids) derived from a human gastric juice protein; reported to be stable in gastric juice. Human pharmacokinetics (half-life, bioavailability) are not established; typically administered parenterally in research settings. Proposed mechanism involves nitric oxide pathway modulation and angiogenesis.