Skip to main content
Professor Peptides
FREE Calculator

Tirzepatide Titration Calculator

Generate a week-by-week tirzepatide dose-escalation plan from the standard 2.5 mg to 15 mg ladder, with the exact date each step begins.

Titration Schedule

Pick your start date to generate the full dose ladder

Optional — defaults to today. Dose steps begin on this date (Week 1).

Standard 2.5 → 15 mg Ladder
  • Weeks 1–4: 2.5 mg (starting dose)
  • Weeks 5–8: 5 mg
  • Weeks 9–12: 7.5 mg (optional)
  • Weeks 13–16: 10 mg
  • Weeks 17–20: 12.5 mg (optional)
  • Week 21+: 15 mg (maintenance)

Dose Ladder With Dates

Choose a start date to see your schedule

Each titration step with its start date

About Tirzepatide
GLP-1/GIP Dual Agonist

Tirzepatide (Mounjaro, Zepbound) is a once-weekly GLP-1 and GIP receptor agonist approved for weight management in adults with obesity or overweight plus a weight-related comorbidity.

How the Ladder Works

Doses escalate from 2.5 mg up to 15 mg over roughly 20 weeks. The lower doses build tolerability; the maintenance dose is where the full effect develops.

Source: schedule mirrors the Zepbound FDA Prescribing Information dose-escalation table.
Escalation Guidance
  • 1Stay on each dose at least 4 weeks — faster escalation is not supported by the label.
  • 2May pause or step down if a dose isn't tolerated — the 5 mg, 10 mg, and 15 mg levels are valid maintenance options.
  • 3Optional intermediate doses (7.5 mg, 12.5 mg) exist for tolerability — not every patient needs every step.
Tip: use this schedule to plan ahead, but base every dose decision on tolerability and clinical guidance.

Medical Disclaimer

Tirzepatide is a prescription medication. This calculator reproduces the FDA-approved dose-escalation schedule for educational reference only — it is not medical advice, and it does not replace a prescription or clinical supervision. Consult a licensed healthcare provider before starting any medication.